Irf7 mouse
IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including the type I interferon genes. In particular, IRF7 regulates many interferon-alpha genes. Constitutive expression of IRF7 is largely restricted to lymphoid tissue, largely plasmacytoid dendritic cells, whereas IRF7 is inducible in many tissues. Multiple IRF7 tra… WebMouse Antibody Type Monoclonal Host Species Rat Immunogen Partial mouse IRF7 recombinant protein (127-487a.a.) expressed in E. coli. Formulation Phosphate-buffered …
Irf7 mouse
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WebIRF7 Antibody (PA5-20281) in IHC Immunohistochemistry of IRF7 in mouse spleen tissue with IRF7 Polyclonal Antibody (Product # PA5-20281) at 5 µg/mL. Product Details Product Specific Information A suggested positive control is 293 cell lysate. PA5-20281 can be used with blocking peptide PEP-0415. Target Information WebApr 12, 2024 · IRF7 suppresses hematopoietic regeneration under stress via CXCR4. The role of interferon regulatory factor 7 in the pathogenicity and immunogenicity of rabies …
WebJul 7, 2024 · It remains possible that IRF7, a homolog of IRF3, compensates for the loss of IRF3 and explains the IRF3-independent resistance to HSV-1 that we observe. ... Mouse primary microglia cells and ... WebIRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood lymphocytes, and …
WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. For Research Use Only. WebMar 7, 2024 · AML-IRF7 −/− mice exhibited accelerated disease progression with intracerebral invasion of AML cells. AML-IRF7 −/− cells showed increased proliferation and elevated leukemia stem cell (LSC)...
WebInterferon regulatory factor 7 (IRF7) is the main transcriptional regulator of type I IFN, and it is crucial for the induction of IFNα/β and the type I IFN-dependent immune response. In this study, we focused on the role of IRF7 in the pathogenicity and immunogenicity of RABV using an IRF7 -/- mouse model.
WebProduct Details. Partial mouse IRF7 recombinant protein (127-487a.a.) expressed in E. coli. Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. The antibody was purified by affinity chromatography. The antibody solution should be stored undiluted between 2°C and 8°C. tsql identity functionWebJul 14, 2016 · IRF3-5D, an active form of IRF3, and IRF7Δ247–467, a constitutively active form of IRF7 were constructed as previously described using pFLAG-IRF3, and pFLAG-IRF7 plasmids as templates 38,39,40 ... phishing facebook meldenhttp://www.informatics.jax.org/allele/allgenoviews/MGI:3577089 tsql how to drop constraintWebJan 18, 2024 · It has been proposed, based on studies of mouse Ifna4 and Ifna2 genes , that late-phase expression of IFNA genes is controlled by Irf7 binding to VRE-A/B, whereas early-phase expression is controlled by Irf3 binding to VRE-C. We show that for many IFNs (63%, 17/27) it is only IRF7 that binds to VRE-A/B, suggesting that late-phase expression ... phishing facebook helpWebJul 25, 2024 · By performing mass-spectrometry analysis of IRF3 and IRF7 isolated from cells treated with a SIRT1 inhibitor, we identified SIRT1-specific lysine-deacetylation sites and confirmed this result by... tsql if not exists create indexWebApr 14, 2011 · IRF7 is a lymphoid-specific factor, which is constitutively expressed in the cytoplasm in B cells, pDCs and monocytes in the spleen, thymus, and peripheral blood … t-sql if exists syntaxWebJan 10, 2024 · IRF7 is the key transcription factor which induces IFNα expression 9, leading to a second wave of type I IFN release. Since IFNα signals via the IFNAR this leads to a positive feedback loop that... t-sql how to escape single quote