Klf5 phosphorylation

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August undefined, 2024

WebApr 14, 2015 · Krüppel-like factor (KLF) 5, which initiates vascular smooth muscle cell (VSMC) proliferation, also participates in Angiotensin (Ang) II-induced vascular remodeling. The protective effect of rosiglitazone on vascular remodeling may be due to their impact on VSMC proliferation. However, the underlying mechanisms involved remain unclear. This … WebJul 23, 2009 · To understand whether the change in KLF5 phosphorylation is responsible for the increased interaction between KLF5 and c-Jun, we detected the levels of phospho-KLF5 in VSMCs treated with Ang II. As shown in Fig. 3 A, Ang II stimulation rapidly induced phosphorylation of KLF5 within 0.5 h, and KLF5 phosphorylation reached the maximum at …

Phosphorylation of Kruppel‐like factor 5 (KLF5/IKLF) at the CBP ...

WebApr 18, 2024 · The mechanism involves the inhibition of protein kinase A (PKA) activity, which is a protein that phosphorylates glycogen synthase kinase-3β (GSK3β). GSK3β is a well-known protein that... WebKrüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, … cityu network

Klf5 KLF transcription factor 5 [ (Norway rat)] - National Center for ...

Web目的探讨锌指转录因子Krüppel样因子5(Krüppel-like factor 5,KLF5)在高糖诱导的血管平滑肌细胞(vascular smooth muscle cells,VSMCs)炎症中的作用及机制.方法体外培养VSMCs,实时定量反转录聚合酶链反应(quantitative real-time polymerase chain reaction,qRT-PCR)、蛋白 … WebFeb 1, 2024 · Resveratrol induced KLF5 phosphorylation in renal HEK293 cells and prevented association of KLF5 with c-Myc. 25 Moreover, KLF5 phosphorylation could modulate its activation status as KLF5-Ser153 phosphorylation by protein kinase C at the CREB binding protein (CBP) interaction site promoted its transactivation function in … WebFeb 1, 2024 · KLF5 inhibition holds therapeutic potential for cardiovascular diseases. Abstract Krüppel-like factors (KLFs) are DNA-binding transcriptional factors, which regulate various pathways that pertain to development, metabolism and other cellular mechanisms. KLF5 was first cloned in 1993 and by 1999, it was reported as the intestinal-enriched KLF. city under the city

Synthetic retinoid Am80 inhibits interaction of KLF5

Tongxinluo inhibits neointimal formation by regulating the …

WebDec 28, 2009 · KLF5 is a downstream signal of the ERK 1/2 and p38 MAPK pathways, and activates the transcription of cyclin D1 gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation. Keywords: Krüppel-like factor 5, cyclin D1, angiotensin II, proliferation, vascular smooth muscle cells Go to: Introduction WebDec 6, 2024 · Furthermore, we detected the levels of klf5 phosphorylation, suggesting klf5 phosphorylation level in HFD group was lower than HFD+RSV group. In parallel, in HEK293 cells, we also observed that HG (25 mmol/L) enhanced the interaction of klf5 with c-Myc and klf5 dephosphorylation, which were reversed by treatment with inhibitor LY294002 and RSV. city under the lakeWebSRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway. Nat Commun. 2024; 8: 16016 ( 影响因子 14.919 ) Guo J, Xie N, Li G, Zhang Y （张岩） , Lv F, Guo S, Feng Y, Cao CM, Xiao RP. p55γ functional mimetic peptide N24 blocks vascular proliferative disorders. city unearths time capsule beneath vance

"WebJun 16, 2024 · Herein, we analyzed KLF5 expression in TCGA and GEO database, as well as prostate cancer tissue microarray, and found that KLF5 expression significantly decreased in prostate cancer... " - Klf5 phosphorylation

Klf5 phosphorylation

Arginine methyltransferase PRMT5 methylates and …

WebNov 16, 2012 · Abstract 2313. Krüppel-like factor 5 (KLF5) is a member of a highly conserved group of transcription factors (the KLF family) that have regulatory roles in … WebDec 10, 2013 · Phosphorylation of KLF5 on serine 406 also enhances interaction with unliganded RARα, which binds to the first zinc finger of the KLF5 DBD, to activate downstream target genes 90, 93. RAR agonists are thought to act via two mechanisms to disrupt the interaction between KLF5 and RARα and subsequently inhibit VSMC …

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WebApr 14, 2024 · Enhancer RNAs (eRNAs) are non-coding RNAs (ncRNAs) transcribed in enhancer regions. They play an important role in transcriptional regulation, mainly during cellular differentiation. eRNAs are tightly tissue- and cell-type specific and are induced by specific stimuli, activating promoters of target genes in turn. eRNAs usually have a very … WebDownload scientific diagram Role of AMPK/mTOR pathway in morusin-induced autophagy in non-small cell lung cancer cells. Cells were treated with morusin (20 μM) at various time periods. (A) The ...

WebApr 4, 2024 · correlation between the KLF5 and ZEB1 transcription levels in the pancreatic tumor tissues The present study has identified that KLF5, a target of miR-145-5p, is a key … WebVarious KLFs, including KLF5, are involved in cancer-related processes, such as epithelial-mesenchymal transition (EMT), invasion, and metastasis (3-6). In addition, studies show …

WebKrüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and …

WebApr 15, 2003 · GST–KLF5 fusion protein was phosphorylated by 125 mM ATP as described above. After the reactions, the bound and phosphorylated GST–KLF5 was washed with GST pull‐down buffer (20 mM HEPES, pH 7.5, 0.1 mM EDTA, 75 mM KCl, 2.5 mM MgCl 2, 0.05% NP‐40) three times.

WebApr 17, 2009 · Protein phosphorylation has been an important mechanism by which a transcription activator recruits coactivators, such as phosphorylation of cAMP response element-binding protein (CREB) at Ser133 leading to the recruitment of CREB-binding protein (CBP) [23], phosphorylation of KLF5 at the CBP interaction region enhancing its … city under the oceanWebKLF5 is a member of the Kruppel-like factor subfamily of zinc finger proteins. It contains three C2H2-type zinc fingers at the carboxyl-terminus that preferentially bind to cis-DNA … city under the city edinburghWebHDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Abnormal … city under the iceWebDec 6, 2024 · Moreover, we tested the klf5 phosphorylation level as well, the result demonstrated that high-fat diet decreased the klf5 phosphorylation level, whereas RSV … city underwater horrorWebApr 11, 2024 · SPI1, HIF1A, STAT1, KLF5, RUNX1, MBD1, SP1, and WT1 may be involved in the regulatory mechanisms of DN development. Our study may provide a potential biomarker or therapeutic locus for the study of DN. ... (Zhang et al., 2024c), STAT1 phosphorylation inhibited the M1 phenotypic transformation of macrophages and suppressed DN … city under the groundWebOct 11, 2024 · HDAC2 phosphorylation-dependent Klf5 deacetylation and RARalpha acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. The present study provides direct evidence that BTEB2 plays a critical role in balloon injury-induced neointimal hyperplasia, which is closely linked to vascular SMC … double wall bag with windowWebNov 15, 2016 · Phosphorylation of KLF5 by PKC enhances the transcriptional activities of KLF5 by promoting its interaction with CREB binding protein . In addition, E3 ubiquitin ligase FBW7, a tumor suppressor, interacts with KLF5 for ubiquitination and degradation [11,12]. Despite understanding of KLF5’s role and its activity regulation in cardiovascular ... cityu new president