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The lysosomal rag-ragulator complex

Splet01. apr. 2010 · DOI: 10.1016/j.cell.2010.02.024 Corpus ID: 2374243; Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino … SpletThe Ragulator-Rag complex is a regulator of lysosomal signalling and trafficking in eukaryotic cells, which plays an important role in regulating cell metabolism and growth …

研究揭示溶酶体mTORC1–TFEB–Rag–Ragulator巨型复合物的结构

Splet25. jun. 2024 · Furthermore, they showed that upon infection with pathogenic Yersinia or its mimic (lipopolysaccharide plus TAK1 inhibitor), a FADD-RIPK1-caspase-8–containing complex was recruited via Rag-Ragulator complex to lysosomal membrane, and this process depended on Rag GTPase activity and Rag-Ragulator lysosomal binding but not … SpletA genome-wide CRISPR screen to uncover mediators of caspase-8–dependent pyroptosis identified an unexpected role of the lysosomal folliculin (FLCN)–folliculin-interacting … c \u0026 e stone masonry https://promotionglobalsolutions.com

The Rag-Ragulator Complex Regulates Lysosome Function and …

SpletLysosomal FLCN-FNIP2 interacts with RagA GDP and, together with Ragulator, blocks the exchange of GDP for GTP on RagA, reducing its GAP activity towards RagC. Upon amino acid stimulation, disassembly of the lysosomal FLCN–FNIP2 complex switches on the GAP activity of FLCN towards RagC, leading to mTORC1 activation [135,137]. Splet25. jun. 2024 · A genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) screen to uncover mediators of caspase-8-dependent pyroptosis identified an … Splet2024年6月25日，中国科学院上海巴斯德研究所刘星团队等人在Science 在线发表题为The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis … c \u0026 e technologies

The GATOR–Rag GTPase pathway inhibits mTORC1 activation by …

Category:New mechanism underlying pyroptosis induced by Yersinia infection

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The lysosomal rag-ragulator complex

The Rag-Ragulator Complex Regulates Lysosome Function and …

Splet近日，中國科學院深圳先進技術研究院合成生物學研究所黃建東團隊與香港大學醫學院等合作完成的最新研究成果以Adenosine synthase A contributes to recurrent Staphylococcus aureus infection by dampenin Splet28. jun. 2024 · 2024年6月25日，来自中国科学院上海巴斯德研究所刘星、美国哈佛医学院Judy Lieberman等研究人员合作在发表了题为“The lysosomal Rag-Ragulator complex …

The lysosomal rag-ragulator complex

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Splet10. apr. 2024 · The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia; RIPK1 activates distinct gasdermins in macrophages and neutrophils upon pathogen blockade of innate ... p38MAPK guards the integrity of endosomal compartments through regulating necrotic death Splet25. jun. 2024 · The Rag-Ragulator supercomplex is composed of nine subunits: Ragulator, a pentameric scaffold (Lamtor1-5) that tethers the complex to the lysosomal membrane by lipidation of Lamtor1 (21, 22); two Rag GTPases (GTP-loaded RagA or RagB and GDP …

Splet29. jun. 2024 · 相关研究结果发表在2024年6月25日的Science期刊上，论文标题为“The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis … SpletThe Rag-Ragulator Complex Regulates Lysosome Function and Phagocytic Flux in Microglia. @article{Shen2016TheRC, title={The Rag-Ragulator Complex Regulates …

SpletThe RRAG heterodimer is tethered to the lysosomal surface by a pentameric protein complex called Ragulator, which is composed of LAMTOR1 to LAMTOR5. ... Intriguingly, … Splet25. jan. 2024 · The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy 1.The phosphorylation of TFEB by the mechanistic target of rapamycin …

Splet12. sep. 2024 · The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy. The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) is unique in its mTORC1 substrate recruitment mechanism, which is strictly dependent on the amino-acid-mediated activation of the RagC GAP FLCN. TFEB …

Splet16. okt. 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with nutrient sufficiency. Exogenous amino acids (AAs), taken up through cell … marc principatohttp://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html c \u0026 e supply albertville alSpletRagulator accelerates the release of GTP from RagC. (A and B) Pulse-chase experiment to determine the GTP (A) and GDP (B) off-rate from the Rag–Ragulator heptamer. An … marc pallozzi esqhttp://www.ebiotrade.com/newsf/2024-6/2024625150353929.htm c \\u0026 e supply albertville alSpletThis complex interacts with Rag proteins, and the Rag-Ragulator complex tethered to the lysosome serves as an amino acid-regulated docking site for mTORC1 that is required for … marc pro discountSplet16. okt. 2024 · The mechanistic target of rapamycin complex 1 (mTORC1) coordinates cell growth with nutrient sufficiency. Exogenous amino acids (AAs), taken up through cell surface transporters, promote mTORC1 lysosomal recruitment and activation ().AAs derived from exogenous protein, acquired through Ras-driven macropinocytosis and trafficked to … marc pridmore interiorshttp://shanghaipasteur.cas.cn/zhxw/202406/t20240624_6715152.html c \u0026 c distributors santa fe nm